Recupera el pelo
Tratamientos alternativos basados en medicina natural
Por AliceCooper  -  Cinturón Negro  - 2977Mensajes
#310386
el aceite de linaza es una fuente increible de ácidos grasos omega 3:

OMEGA3

Los ácidos grasos Omega-3, tales como las que se encuentran en el aceite de pescado azul, se han recomendado para la gestión de las enfermedades inflamatorias crónicas debido a su capacidad para alterar la producción de prostaglandina (producto de la acción de las enzima COX-1 y CoX-2) y ceder a cambios en los parámetros de ciertas enfermedades en pacientes con, por ejemplo, artritis reumatoide.

La linaza a parte contiene lignanos que parece balancear las hormonas...aunque el aceite posee menos contenido que las semillas molidas.

Y sí, yo también encontré info acerca del MSM y puede ser un buen antiinflamatorio, por lo menos a nivel de articulaciones.
Por AliceCooper  -  Cinturón Negro  - 2977Mensajes
#312171
ya incluí la cúrcuma en mi dieta, a diario la uso abundante para aderezar mi arroz integral junto con la pimienta de cayena que sirve para que se absorba mejor y esta última también tiene poder antinflamatorio, vasodilatador y estimulador de la circulación.

no sabe mal si la mezclas con cayena incluso si echas esto en un vaso de zumo de naranja en serio jaja.
Por AliceCooper  -  Cinturón Negro  - 2977Mensajes
#312267
estoy pensando en incluir un alto aporte de omega3 para inhibir las pgd2...ya consumo nueces pero quizá consuma también aceite de hígado de bacalao o cápsulas de aceite de lino...en cápsulas siempre resultan más comodas.
Por Urzaiz  -  Cinturón Blanco  - 23Mensajes
#341719
Mi aporte de acidos grasos:

Omega cool oil, una mezcla de flax (linaza), evening pimrose (onagra), hemp (cañamo?) y pipa de calabaza, 1 o 2 cucharadas a la noche.

http://www.groovyfood.co.uk/pages/groovy_oils.html

Representa que es Omega 3, 6 y 9 en proporcion 2:1:1
Por malagueñocalvo  -  Cinturón Naranja  - 214Mensajes
#441694
Alguno siguió alguna pauta respsecto de las prostangladinas? os sirvió de algo ? utilizastéis algo del hilo este?

He encontrado una buena opción natural para la COX2, se trata del harpagofito, también la bromelina de la piña dicen que es buena inhibidora de la cox2, pero me gusta el harpagofito que parece que tiene más tirón.

COMPOSICIÓN.- Desde los albores del siglo XX, la raíz de esta planta ha sido muy estudiada y analizada descubriéndose en ella más de 40 componentes activos entre los que destacan los glucósidos monoterpénicos del grupo de los irioides con un 0,52% al 3%. Entre los irioides el mayor constituyente es el harpagósido, responsable principal de las propiedades de la planta.

Cumaroll- harpágido, procúmbido, son otros de sus componentes junto a flavonoides, sustancias fenólicas, fitosteroles libres y combinados, triterpenos y esteroides.

PROPIEDADES Y ACCIÓN.- La comisión E del Ministerio de Sanidad Alemán ha aprobado las siguientes indicaciones para el harpagofito “artralgia, artritis, dispepsia”. La propiedad más estudiada, conocida y contrastada de esta planta es su acción antiinflamatoria, por esto, se recomienda en casos de dolores articulares, reumáticos, artrósicos y artríticos. Reduce de forma notable la sensación de dolor y mejora el movimiento sin aparecer efectos adversos por lo que puede asociarse a otros fármacos antiinflamatorios a fin de reducir la dosis de éstos.

También estimula la recuperación por traumas. Es importante apuntar que los irioides del harpagofito tienen una acción periférica, con respuestas musculares y vasculares, más que una acción analgésica central por lo que está especialmente indicado y es particularmente activo en personas de edad avanzada.

Digestiva y estomacal se usa en el tratamiento de problemas gastrointestinales. Su contenido en principios amargos le confiere esta propiedad, por la que se utiliza de forma tradicional en el sur de África, de donde es originario. Asimismo tiene una acción colerética que aumenta la producción de bilis mejorando la función digestiva. Estimula las papilas gustativas, las cuales por acción refleja aumentan la producción de jugos gastrointestinales mejorando el apetito.

Además de lo mencionado el harpagofito es muy activo y recomendable en casos de LUMBALGIAS. El extracto de harpagofito inhibe de forma natural los TNF –alfa, más concretamente la proteinquinasa intracelular, que ejerce como mediador intracelular del dolor. Es por esto que tiene muy similar eficacia a los medicamentos de síntesis pero sin los efectos perniciosos de éstos.

ESTUDIOS CLÍNICOS

En la segunda mitad del siglo XX, sobre todo en Alemania, se han realizado numerosos estudios a fin de confirmar la actividad y efectividad de la raíz de harpagofito como ANTIINFLAMATORIO y ANALGÉSICO. Laudahn et al realizaron un estudio con 130 pacientes con dolor de espalda no radicular. Concluyen que 480 mg/d de extracto de planta es eficaz en el tratamiento crónico del dolor de espalda constatando un excelente cumplimiento y tolerabilidad.

En otro estudio piloto, doble ciego y aleatorizado realizado por Chrubasik S, se compara el extracto de harpagofito con un inhibidor selectivo de la ciclo-oxigenasa –2, en 44 pacientes. Aunque el número de pacientes es pequeño, el estudio concluye que la eficacia y seguridad del extracto harpagofito lo hace recomendable para la mejora del dolor de espalda crónico no específico.

Según los resultados de algunos ensayos, los principios activos de esta raíz son capaces de inhibir la producción de diversas citoquinas que intervienen en la inflamación (como la IL1-beta, TNF alfa). Por otro lado, reducen la síntesis de PGE2 y de óxido nítrico al inhibir la expresión de enzimas como el COX-2. Por estos motivos, según afirma el doctor Bernad “su mecanismo de acción está en relación con la inhibición de sustancias implicadas en los mecanismos de la inflamación, es por esto que disminuye la síntesis de citoquinas, reduce la inflamación y alivia los dolores”.

Algunos estudios in vitro muestran que el extracto metanólico de harpagofito, tiene un efecto protector frente a arritmias inducidas. Tras la administración oral de 600 mg de extracto de planta (25% de harpagosidos) a varios voluntarios, se comprobó que los niveles máximos de harpagósido en sangre se producían a los 80 minutos, seguido de un descenso rápido, apareciendo un segundo pico a las 8 horas. La presencia media del harpagósido en sangre fue de 5,6 horas. En resumen, los resultados globales de los estudios (4-8 semanas) demuestran de forma constante una mejoraría del dolor de espalda no específico y del dolor osteoastrítico de cadera y rodilla.

OTRAS PROPIEDADES del Harpagofito:

DEPURATIVO: Facilita la eliminación de ácido úrico por la orina; por lo que mejora los casos de gota y muchas artritis.

ANTIESPASMÓDICO: Actúa como relajante sobre espasmos intestinales, colon irritable, cólicos biliares y renales.

COLESTEROL: Colabora en el descenso de los índices de colesterol en sangre.

CONTRAINDICACIONES.- Contraindicado en casos de ÚLCERA GASTRODUODENAL Y GASTRITIS, OBSTRUCCIÓN DE LAS VÍAS BILIARES Y COLON IRRITABLE.

No emplear en el embarazo y la lactancia salvo por prescripción profesional. El éxito del harpagofito, es que normalmente siempre sienta bien y a diferencia de los fármacos antiinflamatorios no provoca irritación gástrica.

INTERACCIÓN CON MEDICAMENTOS.- No se han descrito, sin embargo, es conveniente vigilar ante posible interacción con medicaciones antiarrítmicas.
Por malagueñocalvo  -  Cinturón Naranja  - 214Mensajes
#441805
Root extract from Harpagophytum for stimulating hair growth Traducido del alemán
DE 102006043766 A1
Extracto traducido del alemán
The present invention relates to the use of an agent comprising active ingredients, which are obtainable from plants of the genus Harpagophytum for the treatment of hair, in particular for the revitalization of hair, reactivation of the hair root, activation of hair follicles, promoting or enhancing the growth of hair, thickening hair, treatment of hair loss and conditioning hair.
Reclamaciones (16) traducidos del alemán

Use of an agent comprising active ingredients, which are obtainable from plants of the genus Harpagophytum for the treatment of hair.
Use according to claim 1, characterized in that the active ingredients of pressed juice and / or extracts of plants of the genus Harpagophytum obtained.
Use according to claim 2, characterized in that the extracts are aqueous extracts, or hydroalcoholic extracts or alcoholic extracts or mixtures thereof.
Use according to claim 3, characterized in that, in aqueous-alcoholic or alcoholic extracts of the alcohol is selected from the group consisting of methanol, ethanol, propanol, isopropanol. Propylene glycol.
Use according to claim 4, characterized in that, in aqueous-alcoholic extracts, the ratio of alcohol to water is between 1:1 to 1:5, is preferably between 1:1 to 1:2 or 1:3.
Use according to one of claims 1 to 5 for the revitalization of hair, reactivation of the hair root, activation of hair follicles, promoting or enhancing hair growth, hair thickening, hair loss treatment and hair conditioning.
Use according to one of the preceding claims 1 to 6, characterized in that the Harpagophytum selected from Harpagophytum procumbens.
Use according to one of the preceding claims 1 to 7, characterized in that the active ingredients, obtained from the leaves, flowers, stems, roots, tubers and / or seeds of Harpagophytumpflanze.
Use according to one of the preceding claims 1 to 8, characterized in that the proportion of active ingredients of Harpagophytumpflanze from 0.001 to 10% by weight, in particular 0.01 to 5% by weight in the total composition.
Use according to one of the preceding claims 1 to 9, characterized in that the agent includes additional components selected from the group consisting of protein hydrolysates, film-forming substances other hair-growth stimulating agents, nonionic surfactants, anionic surfactants, zwitterionic surfactants, ampholytic surfactants, nonionic polymers thickening agents, perfume oils, dyes, light stabilizers, antioxidants, anti-dandruff agents, propellants, reducing agents.
Use according to one of the preceding claims 1 to 10, characterized in that said agent is a hair treatment composition, in particular shampoo, hair rinses, hair gel, hair lotion, hair treatment, hair cream, hair lotion, hair spray and hair tincture.
Use according to one of the preceding claims 1 to 11, characterized in that hair growth is stimulated and the hair roots, in particular at locations where hair growth is set for a long time, is reactivated.
Use according to one of the preceding claims 1 to 12, characterized in that reactivation by suppression and / or reducing the haarwuchsinhibierenden genes is effected in the dermal papilla.
A hair treatment composition comprising active ingredients, which are obtainable from plants of the genus Harpagophytum.
A method for revitalizing the hair, reactivation of the hair root, activation of hair follicles, promoting or enhancing the growth of hair, thickening hair, treatment of hair loss and hair conditioning, characterized in that one to be used is an agent according to claim 14 or any one of claims 1 to 13 Central to the hair, scalp, or hairy skin on skin where the hair growth is set for a long time, but where the hair growth is desired, applies.
The method of claim 15, wherein the hair growth and the hair roots are stimulated and reactivated, characterized in that the dermal papilla cells in haarwuchsinhibierende genes repressed and / or reduced.

Descripción traducido del alemán

[0001]
The present invention relates to the use of an agent comprising active ingredients, which are obtainable from plants of the genus Harpagophytum for the treatment of hair.
[0002]
Human skin with your appendages organ is a very complex structure, which consists of a number of different cell types. Every living cell of this body is able to respond to signals from their internal and external environment. These reactions of the cells can be realized through an orderly regulation of gene and protein level, so that the metabolism of the cells of your skin and appendages is not static but very dynamic. However, the reactions of the skin and / or its appendages to changes in the environment can not be considered as responses of individual, isolated cells. Rather, each cell is connected to a complex communication network. The network includes, for example, the communication between the cells of the epidermis, and cells of the dermis. At the communication between the cells of the skin and / or its appendages, etc. signaling molecules involved such as interleukins, growth factors (eg, KGF, EGF and FGF).
[0003]
The aging process is a fundamental biological process that is found in almost all living organisms. Accordingly, the human skin is affected by this phenomenon. Aging of the skin presents itself as a progressive process that leads to a loss of skin homeostasis. It is influenced by endogenous and exogenous factors. While the endogenous aspects run as "genetically controlled program," Environmental influences such as UV light are responsible for the exogenous factors.
[0004]
The amount of active ingredient hair, which can usually transdermally and specifically transfollicularly penetrate to the hair bulb, is very low and depends mainly on the physicochemical properties of the substance itself (eg size, charge, lipophilicity) and the choice of formulation from.
[0005]
Hair follicle cells are a genetically defined cycle of growth, regression, and resting phase. The hair follicle is thus the only organ that constantly renews itself and thus one has a function of the respective growth phase, unique metabolism. Thus, the metabolism of the hair follicle is almost entirely in the resting phase to a standstill and is also initiated new with each new start of another cycle.
[0006]
Is controlled by the cycle of a small, highly specialized cell population in the hair bulb, dermal papilla cells, which through a complex set of molecular signals specific to each phase of the hair cycle, hair growth control (Botchkarev VA et al. (2003) J Investig Dermatol Symp Proc 8:46-55).
[0007]
The genus of devil's claw (Harpagophytum) belongs to the family of sesame plants (Pedaliaceae) and includes another kind Trampelklette (Harpagophytum procumbens) is called.
[0008]
Harpagophytum contains a number of known ingredients that are already used in medicine. Merely the underground storage ramified roots (secondary roots) of Harpagophytums be used medicinally. About the constituents of the aerial parts, little is known.
[0009]
For example, the bitterness of Iridoiglykoside Harpagophytums are anti-inflammatory, decongestant and analgesic weak.
[0010]
For digestive complaints Devil's Claw (Harpagophytum) the promotion of gastric acid and bile production is used.
[0011]
It is also known that the devil's claw builds cartilage tissues and therefore soothing affects sciatica and joint pain.
[0012]
In EP0524873 B1 disclosed the use of therapeutic compositions for the preparation of Harpagophytonwurzelextrakten against skin itching.
[0013]
In US6541045 B1 is a herbal composition for the control of inflammation is disclosed which contains the devil's claw next to perennial Japanese knotweed, Grapeskin, and Syzygium.
[0014]
It has now surprisingly been found that upon application of compositions comprising active ingredients, which are obtainable from plants of the genus Harpagophytum on your hair, scalp, hairy skin or on skin where the hair growth is set for a long time, but where the hair growth is desired, reactivates the hair root and hair growth is significantly improved.
[0015]
It was surprisingly found that products containing active ingredients that are extracted from plants of the genus Harpagophytum, are suitable the hair to strengthen and / or to thicken.
[0016]
The present invention therefore relates to the use of an agent comprising active ingredients, which are obtainable from plants of the genus Harpagophytum for the treatment of hair, in particular for the stimulation of hair growth, hair follicle and for reactivation of strengthening (thickening) of the hair.
[0017]
Preferably Harpagophytum procumbens is used by the company Frutarom. Active substances obtainable from plants of the genus Harpagophytum procumbens, are according to the invention, the plant itself, its plant parts, extracts and pressed juice of Harpagophytum procumbens, and to profit from these extracts, active ingredients to understand.
[0018]
The pressed juices or extracts are preferably obtained from the leaves, flowers, stems, roots, tubers and / or seeds of Harpagophytumpflanze, most preferably they are derived from the roots.
[0019]
Also preferred are aqueous extracts or aqueous-alcoholic extracts or aqueous-organic or alcoholic extracts of Harpagophytumpflanze.
[0020]
The extracts which can be prepared in the conventional manner with water, as well as polar or non-polar organic solvents and mixtures thereof. Extracts may be obtained by extraction with ethanol or water / ethanol mixtures, and pressed juice are preferred.
[0021]
In addition to the active compounds from the Harpagophytumpflanze ethanol can also be obtained by extracting with other alcohols, such as methanol, propanol, isopropanol, Isopronaol and / or propylene glycol.
[0022]
Both the extracts and the original extractant extracts / juice press in water or other organic solvents and / or mixtures thereof, especially ethanol, and ethanol / water mixtures. Preference is pressed or extracted material is used as a solid, the solvent (as gently as possible, in particular) has been withdrawn. But it can also be used such extracts / juice press, where the solvent was removed in part, so that a thickened extract / pressed juice is used. In particular, the preparations and / or pressed juices are used in solid form.
[0023]
Preferably, the ratio of alcohol to water in the aqueous-alcoholic extract from 1:1 to 1:5, in particular 1:1 to 1:2 or 1:3, most preferably 1:3
[0024]
Furthermore, it was found that the use of agents containing active substances which are obtainable from plants of the genus Harpagophytum lead to a stimulation of hair growth and a strengthening of the vital hair (Example 7). The hair is strengthened and revitalized, and thus better able to repair damage and build new hair.
[0025]
A further advantage of the present invention is that the compositions comprising active ingredients, which are obtained from Harpagothytumpflanzen are able to positively influence the growth of hair by hair-specific inhibiting specific genes are repressed or reduced. Repression or reduction of inhibitory genes, results in the hair root can be reactivated. In addition, the hair structure is already affected in hair follicles, so that hair can grow strong and healthy.
[0026]
Furthermore, it was found that the hair be positively influenced in its growth and its metabolism by the application of these resources.
[0027]
The penetration of active ingredients to the follicle is usually difficult because the corresponding target, the dermal papilla and the ORS keratinocytes, is about 2 mm deep embedded in the scalp. The use of liposomes increased the penetration of an active ingredient, so that liposomal encapsulated compositions containing active ingredients from Harpagophytumpfanzen act very well. It has surprisingly been found that these compositions even show a sufficient penetration to the site of action, if the use of liposomes for formulation is technically not possible.
[0028]
The active ingredients, which are obtainable from plants of the genus Harpagophytum, are preferably used in hair treatment compositions, in particular shampoos, hair rinses, hair gels, hair lotions, hair conditioners, hair creams, hair lotions, hair sprays and Haartinkturen.
[0029]
The use of these agents is usually carried out topically, wherein the means simply the hair on the scalp or on skin where the hair growth is set for some time in particular and will be reactivated by spray, massage, apply and / or knead is applied.
[0030]
After the application of the agent in the form of hair gel, hair lotion, hair treatment, hair cream, hair lotion, hair spray and hair tincture, it is usually not necessary to rinse the hair or the scalp once or treat with further additional funds to a positive effect of the agent to reach. The agent may remain on the hair.
[0031]
For shampoo and hair rinses, the agent can be washed out after an exposure. This flushing can be done with pure water or a commercially available shampoo. Exposure times of 10 seconds to 15 minutes proved to be sufficient in most cases.
[0032]
Regardless of the exact end of the treatment, it has proved to be advantageous, at a temperature of 20 to 55 ° C, in particular from 35 to 40 ° C to apply the agents.
[0033]
However, it is advantageous if means are used according to their application, the active compounds of the Harpagophytumpflanze can remain in the hair and are not washed. This is granted to the hair follicles a time improved penetration of active ingredients.
[0034]
With regard to the manner in which the funds can be applied to the hair, but there are no fundamental limitations.
[0035]
Active substances obtainable from plants of the genus Harpagophytum, preferably the juices and / or extracts of Harpagophytum are preferred in the above compositions in amounts of 0.001 to 10 wt -%, based on the total preparation. Amounts of 0.01 to 5 weight -% being particularly preferred, amounts of from 0.01 to 5 weight -% are especially preferable, and amounts of from 0.01 to 2 wt -% are especially preferred.
[0036]
According to the invention of particular interest are hair tonics, especially as to the remaining hair (leave-on) formulation. These are preferably used at room temperature, the alcohol content is preferably measured in the range from about 30% to about 35% and the pH was at about pH 7 mooring. In particular to hair tonics, the use of encapsulated active ingredients in liposomes, which are available as proven Harpagophytum advantageously derived from plants of the genus.
[0037]
The encapsulation of the active substances obtainable from extracts and / or from the plant of the genus Pressäften Harpagophytum, followed by encapsulation in liposomes being especially preferred. Such liposomes can be especially used in hair tonics.
[0038]
In addition to the active ingredients of the liposome encapsulated Harpagophytumpflanze other substances may be encapsulated, which are appropriate for the application.
[0039]
Although the use of the aforementioned hair treatment agents are preferred according to the products containing the active ingredients of plants of the genus Harpagophytum, particularly preferably pressed juice or (ethanolic) extracts of Harpagophytum procumbens, also other hair treatment products such as hair dyes and waving agents, are added. These agents then possibly the known direct dyes, precursors for oxidation dyes (developer and coupler components) and oxidizing agent or reducing agent.
[0040]
Advantageously, the means can thus protect your hair from the stress at coloring, activate the hair follicles and at the same time reduce skin irritation caused by the wave or hair dye or alleviate.
[0041]
When assembling the compositions of the invention containing preparations, for example, creams, lotions, solutions, water, emulsions such as W, O/W-, PIT emulsions (emulsions according to the teaching of the phase inversion, called PIT), microemulsions and multiple emulsions, gels, sprays, aerosols and foam aerosols suitable. These are usually formulated in aqueous or aqueous-alcoholic base. As alcoholic component like are lower alkanols and polyols, such as propylene glycol and glycerol is used. Ethanol and isopropanol are the preferred alcohols. Water and alcohol may be present in the aqueous-alcoholic base in a weight ratio of 1:10 to 10:1. Water and aqueous-alcoholic mixture containing up to 50 wt -%, in particular up to 25 wt -% of alcohol, based on the mixture of alcohol / water, may be preferred in the present invention basis. The pH of these formulations may range from values ​​of 2-11 in principle. It is preferably between 2 and 7, wherein values ​​of 3 to 5 are particularly preferred. To set this pH can be used virtually any suitable acid or base for cosmetic purposes. Acids are usually used as food acids. Under food acids such acids are understood to be included within the usual food intake and have positive effects on the human organism. Food acids are for example acetic acid, lactic acid, tartaric acid, citric acid, malic acid, ascorbic acid and gluconic acid. In the invention, the use of citric acid and lactic acid is particularly preferred. Preferred bases are ammonia, alkali metal hydroxides, triethanolamine and N, N, N ', N'-tetrakis (2-hydroxypropyl) ethylenediamine.
[0042]
The compositions may be formulated as a single-or dual-chamber system.
[0043]
Besides the obligatory ingredients of Harpagophytumpflanze, the agent, in principle contain all the other skilled in the art for such cosmetic products known components.
[0044]
Thus, the compositions can additionally include protein hydrolysates. Preferably, there are cationized protein, wherein the protein underlying the animal, for example, collagen, milk or keratin of the plant, such as wheat, corn, rice, potatoes, soy or almond, from marine life forms, such as from fish collagen or algae, or biotechnology-derived protein hydrolysates, can come. The protein hydrolysates the cationic derivatives are based can be obtained from both types of hydrolysis of the corresponding proteins by a chemical, in particular alkaline or acidic hydrolysis by enzymatic hydrolysis and / or a combination. The hydrolysis of proteins is generally a protein hydrolyzate with a molecular weight distribution of from about 100 daltons up to several thousand daltons. Preferably, such cationic protein whose underlying protein fraction has a molecular weight of 100 to 25,000 daltons, preferably from 250 to 5000 daltons. Furthermore, to understand quaternized cationic protein amino acids and mixtures thereof. The quaternization of protein hydrolysates or amino acids is often (2-hydroxy-3-chloro-n-propyl)-ammonium halides carried out using quaternary ammonium salts such as N, N-dimethyl-N-(n-alkyl)-N-. The cationic protein hydrolysates can also be further derivatized. As typical examples of the cationic protein, and - names in the "International Cosmetic Ingredient Dictionary and Handbook", (seventh edition, 1997, The Cosmetic, Toiletry, and Fragrance Association 1101 17th Street, NW, Suite 300, Washington - derivatives under the INCI were , DC 20036-4702), and commercially available products include: Cocodimonium Hydroxypropyl Hydrolyzed Collagen, Cocodimopnium Hydroxypropyl Hydrolyzed Casein, Cocodimonium Hydroxypropyl Hydrolyzed Collagen, Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin, Cocodimonium hydroxypropyl hydrolyzed keratin, Cocodimonium Hydroxypropyl Hydrolyzed Rice Protein, Hydrolyzed Silk Cocodimonium hydroxypropyl , Cocodimonium Hydroxypropyl Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein Hydroxypropyl Cocodimonium, Cocodimonium Hydroxypropyl Silk Amino Acids, Hydroxypropyl Arginine Lauryl / myristyl ether HCl, Hydroxypropyltrimonium Gelatin, Hydrolyzed Casein Hydroxypropyltrimonium, Hydroxypropyltrimonium Hydrolyzed Collagen, Hydrolyzed Hydroxypropyltrimonium conchiolin protein Hydroxypropyltrimonium Hydrolyzed Keratin, Hydrolyzed Rice Hydroxypropyltrimonium Bran Protein, Hydrolyzed Silk Hydroxyproypltrimonium, Hydroxypropyltrimonium Hydrolyzed Soy Protein, Hydroxypropyl Hydrolyzed Vegetable Protein, Hydroxypropyltrimonium Hydrolyzed Wheat Protein, Hydrolyzed Wheat Protein Hydroxypropyltrimonium / siloxysilicates, Laurdimonium Hydroxypropyl Hydrolyzed Soy Protein, Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein, Hydrolyzed Wheat Protein Hydroxypropyl Laurdimonium / siloxysilicates, Lauryldimonium Hydroxypropyl Hydrolyzed Casein, Lauryldimonium Hydroxypropyl Hydrolyzed Collagen, Lauryldimonium hydroxypropyl hydrolyzed keratin, Lauryldimonium Hydroxypropyl Hydrolyzed Silk, Lauryldimonium Hydroxypropyl Hydrolyzed Soy Protein, Steardimonium Hydroxypropyl Hydrolyzed Casein, Steardimonium Hydroxypropyl Hydrolyzed Collagen, Steardimonium hydroxypropyl hydrolyzed keratin, Steardimonium Hydroxypropyl Hydrolyzed Rice Protein, Hydrolyzed Silk Steardimonium hydroxypropyl , Steardimonium Hydroxypropyl Hydrolyzed Soy Protein, Steardimonium Hydroxypropyl Hydrolyzed Vegetable Protein, Hydrolyzed Wheat Protein Steardimonium hydroxypropyl, hydroxyethyl Steartrimonium Hydrolyzed Collagen, Quaternium-76 Hydrolyzed Collagen, Quaternium-79 Hydrolyzed Collagen, Quaternium-79 Hydrolyzed Keratin, Quaternium-79 Hydrolyzed Milk Protein, Quaternium -79 Hydrolyzed Silk, Quaternium-79 Hydrolyzed Soy Protein, Quaternium-79 Hydrolyzed Wheat Protein.
[0045]
Furthermore, additional film-forming substances can be incorporated into the formulations that attach to the hair and thus thicken it directly felt. Suitable film formers are known in the art and selected for example from polymers such as polyvinyl alcohol or polyvinyl pyrrolidone and their copolymers.
[0046]
According to a particularly preferred embodiment, such means comprises a hair growth stimulating agent. Particular preference is used as a hair-growth stimulating agents are those compounds selected from 5-á-reductase inhibitors, minoxidil (6-piperidino-2 ,4-pyrimidinediamine-3-oxide) and Aminexil (Diaminopyrimidinoxid). Than 5-á-reductase inhibitors are particularly functional C2-C12 carboxylic acids and their physiologically acceptable metal salts, particularly 10-hydroxy-decanoic acid, 10-Hydroxydecensäure and their derivatives, derivatives of C3-C9 polyols, phenol derivatives, plant extracts, fragrances, flavonoids, isoflavonoids, 6,7-disubstituted or 2,2-Dialkylchromanen chromenes, aluminum chlorohydrate, 2-phenylethanol, etidronic acid, 7-acetyl-1 ,1,3,4,4,6-hexamethyltetraline, Tropolonderivaten, esters of sulfuric acid with alkoxylated C8-C18 fatty alcohols and their physiologically acceptable metal salts, esters of phosphoric acid and triphosphoric acid with monohydric to hexahydric hydroxy, silicic acid esters from marine organisms be isolated mycosporine-like amino acids (MAA), and quaternary silicone compounds.
[0047]
Derivatives, in particular the salts, esters and amides are to be understood. Very particular preference is given to 10-hydroxy-decanoic acid, 10-Hydroxydecensäure and finasteride (N-tert-butyl-3-oxo-4-aza-5a-androst-1-en-17â-carboxamide) and its derivatives.
[0048]
It has been found that the hair growth stimulatory effect of the active substances by their use in compositions comprising active ingredients, which are obtainable from plants of the genus can be Harpagophytum, improved. Particularly preferred are those compositions which in addition to the active ingredients, which are obtainable from Harpagophytumpflanzen, particularly preferably (ethanol) or extracts of Harpagophytum procumbens Press juice, at least one further active compound selected from 10-hydroxydecanoic acid, 10-Hydroxydecensäure, minoxidil and finasteride included. Most preferably, the hair growth stimulating agent is also in this combination selected from minoxidil and finasteride.
[0049]
Other active ingredients, excipients and additives are, for example,
- Non-ionic surfactants such as alkylphenol polyglycol ethers, fatty acid polyglycol esters, fatty acid amide, fatty amine polyglycol ethers, alkoxylated triglycerides, in particular ethoxylated castor oil, alk (en) yloligoglucoside, fatty acid-N-alkyl, polyol fatty acid esters, sugar esters, sorbitan esters and polysorbates. If the nonionic surfactants contain polyglycol ether chains, they may have a conventional or narrow homolog distribution.
- Anionic surfactants, especially alkyl sulfates, alkyl polyglycol ether sulfates and ether carboxylic acids having 10 to 18 carbon atoms in the alkyl group and up to 12 glycol ether groups in the molecule, soaps ether groups and dialkyl esters having 8 to 18 carbon atoms in the alkyl group and Sulfobernsteinsäuremono alkylpolyoxyethyl- ester having 8 to 18 carbon atoms in the alkyl group and 1 to 6 oxyethyl groups,
- Zwitterionic surfactants, in particular the so-called betaines, such as N-alkyl-N, N-dimethyl ammonium glycinate, such as coconut alkyl dimethyl ammonium glycinate, N-Acylaminopropyl-N, N-dimethyl, for example cocoacylaminopropyldimethylammonium glycinate, and 2-alkyl-3 -carboxymethyl-3-hydroxyethyl imidazolines containing 8 to 18 carbon atoms in the alkyl or acyl group as well as the Kokosacylaminoethylhydroxyethylcarboxymethylglycinat,
- Ampholytische surfactants such as N-alkyl glycines, N-alkyl propionic acids, N-alkyl aminobutyric acids, N-Alkyliminodipropionsäuren, N-hydroxyethyl-N-alkylamido, N-alkyltaurines N alkylsarcosines, 2-alkylamino and alkyl amino acetic acids containing around 8 to 18 carbon atoms in the alkyl group,
- Non-ionic polymers, for example vinylpyrrolidone / vinyl acrylate copolymers, polyvinylpyrrolidone and vinylpyrrolidone / vinyl acetate copolymers and polysiloxanes,
- Thickeners such as agar-agar, guar gum, alginates, xanthan gum, gum arabic, karaya gum, locust bean flour, linseed gums, dextrans, cellulose derivatives such as methyl cellulose, hydroxyalkyl cellulose and carboxymethyl cellulose, starch fractions and derivatives, such amylose, amylopectin and dextrins, clays such as bentonite or fully synthetic hydrocolloids such as polyvinyl alcohol,
- Structure such as maleic acid and lactic acid,
- Hair-conditioning compounds such as phospholipids, for example soya lecithin, egg lecithin and cephalin, as well as silicone oils,
- Perfume oils, dimethyl isosorbide and cyclodextrins
- Solvents and solubilizers such as ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol and diethylene glycol,
- Symmetrical and asymmetrical, linear and branched dialkyl ethers having a total of from 12 to 36 carbon atoms, preferably 12 to 24 carbon atoms, such as di-n-octyl ether, di-n-decyl ether, di-n-nonyl ether, di-n -undecyl ether and di-n-dodecyl, n-hexyl, n-octyl, n-octyl-n-decyl ether, n-decyl, n-undecyl ether, n-undecyl, n-dodecyl ether and n-hexyl n-undecyl ether and di -tert-butyl ether, di-iso-pentyl ether, di-3-ethyldecylether, tert-butyl n-octyl ether, iso-pentyl,-n-octyl ether and methyl-2-pentyl-n-octyl ether,
- Fatty alcohols, in particular linear and / or saturated fatty alcohols containing 6 to 30 carbon atoms, and monoesters of fatty acids with alcohols having 6 to 24 carbon atoms,
- Fatty acids
- Fiber-structure-improving agents, in particular mono-, di-and oligosaccharides such as glucose, galactose, fructose, fruit sugar and lactose,
- Conditioning agents such as paraffin oils, vegetable oils, such as sunflower oil, orange oil, almond oil, wheat germ oil and peach kernel oil and phospholipids, for example soya lecithin, egg lecithin and cephalin,
- Quaternized amines such as 1-methyl-2-alkylamidoethyl alkylimidazolinium methosulfate,
- Defoamers such as silicones,
- Dyes for coloring the agent,
- Anti-dandruff agents such as piroctone olamine, zinc and omadine climbazole,
- Sunscreens, particularly derivatized benzophenones, cinnamic acid derivatives, and triazines,
- Further substances for adjusting the pH value, such as α-and β-hydroxycarboxylic acids
- Ingredients such as allantoin and bisabolol,
- Cholesterol,
- Bodying agents such as sugar esters, polyol esters or polyol alkyl,
- Fats and natural or synthetic waxes,
- Fatty acid,
- Chelating agents such as EDTA, NTA, β-alanine diacetic acid and phosphonic acids,
- Swelling and penetration substances such as glycerol, propylene glycol monoethyl ether, carbonates, hydrogen carbonates, guanidines, ureas, and primary, secondary and tertiary phosphates,
- Clouding agents such as latex, styrene and styrene / acrylamide copolymers
- Pearlescent agents such as ethylene glycol mono-and di-stearate and PEG-3 distearate,
- Pigments,
- Reducing agent, such as thioglycolic acid and derivatives thereof, thiolactic acid, cysteamine, thiomalic acid, and α-mercaptoethanesulfonic acid,
- Propellants, such as propane-butane mixtures, N2O, dimethyl ether, CO2 and air,
- Antioxidants.
[0050]
Fatty alcohols which may be used are saturated, mono-or polyunsaturated, branched or unbranched C6-C30 fatty alcohols, preferably C10-C22 and most preferably C12-C22 carbon atoms. Used according to the invention are, for example, decanol, octanol, octenol, dodecenol, decenol, octadienol, dodecadienol, Decadienol, oleyl alcohol, erucic, ricinolyl, stearyl alcohol, isostearyl alcohol, cetyl alcohol, lauryl alcohol, myristyl alcohol, arachidyl, caprylic alcohol, capric alcohol, linoleic, linolenyl and behenyl , and Guerbet alcohols thereof, this list should be exemplary and not limiting character. However, the fatty alcohols are preferably derived from natural fatty acids, which can be assumed to be obtained from the esters of fatty acids by reduction usually. According to the invention can be used are also those fatty alcohol cuts, which are produced by reduction of naturally occurring triglycerides such as beef tallow, palm oil, peanut oil, rapeseed oil, cottonseed oil, soybean oil, sunflower oil and linseed oil or from their transesterification products with corresponding alcohols, fatty acid esters, and thus represent a mixture of different fatty alcohols. Such substances are, for example, under the names Stenol ®, eg Stenol ® 1618 or Lanette ®, eg Lanette ® O or Lorol ®, eg Lorol ® C8, Lorol ® C14, Lorol ® C18, Lorol ® C8-18, HD Ocenol ®, Crodacol ®, eg Crodacol ® CS, Novol ®, Eutanol ® G, Guerbitol ® 16, ® 18 Guerbitol, Guerbitol ® 20, ® 12 Isofol, Isofol ® 16, Isofol ® 24, ® 36 Isofol, Isocarb ® 12, ® 16 Isocarb or Isocarb ® 24 for sale. Of course, the present invention also wool wax alcohols, such as they are available for purchase, for example, under the names of Corona ®, White Swan ®, Coronet ® or Fluilan ®, are used. The fatty alcohols are used in amounts of 0.1-30 wt -%, based on the total preparation, preferably in amounts of 0.1-20 wt -% is used.
[0051]
Fatty acids which can be used are linear and / or branched, saturated and / or unsaturated fatty acids having 6-30 carbon atoms. Preferably, fatty acids with 10-22 carbon atoms. This includes, for example, would be to call the isostearic as the commercial products Emersol 871 ® and 875 ® Emersol, and isopalmitic as the commercial product Edenor.RTM ® IP 95, and all other products sold under the trade names Edenor.RTM ® (Cognis) fatty acids. Further typical examples of such fatty acids are caproic acid, caprylic acid, 2-ethylhexanoic acid, capric acid, lauric acid, isotridecanoic acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, elaidic acid, petroselinic acid, linoleic acid, linolenic acid, elaeostearic acid, arachic acid, gadoleic acid, behenic acid and erucic acid and technical mixtures thereof, for example, in the pressure hydrolysis of natural fats and oils, in the oxidation of aldehydes from Roelen oxo synthesis or the dimerization of unsaturated fatty acids occur. Particularly preferred are usually the fatty cuts, which are obtainable from coconut oil or palm oil, particularly preferred is usually the use of stearic acid.
[0052]
The use amount here 0.1-15% by weight based on the total composition. The amount is preferably 0.1-10% by weight, said amounts may be 0.1-5% by weight of very particularly advantageous.
[0053]
Natural or synthetic waxes can be used according to the invention are solid paraffins or isoparaffins, montan wax, carnauba wax, beeswax, candelilla, ozokerites, ceresin, spermaceti wax, sunflower wax, fruit waxes such as apple wax or citrus wax, micro waxes, PE or PP. Such waxes are available, for example, from Kahl & Co., Trittau.
[0054]
The amount used is 0.1-50% by weight based on the total composition, preferably 0.1-20% and more preferably 0.1-15% by weight based on the total composition.
[0055]
The natural and synthetic cosmetic oil bodies, which can be advantageously used according to the invention are, for example to include:
- Vegetable oils. Examples of such oils are sunflower oil, olive oil, soybean oil, rapeseed oil, almond oil, jojoba oil, orange oil, wheat germ oil, peach kernel oil and the liquid fractions of coconut oil. Also suitable are other triglyceride oils as the liquid fractions of beef tallow and synthetic triglyceride oils.
- Liquid paraffin oils, isoparaffin oils and synthetic hydrocarbons and di-n-alkyl ethers with a total of 12 to 36 carbon atoms, preferably 12 to 24 carbon atoms, such as di-n-octyl ether, di-n-decyl ether, di-n- nonyl ether, di-n-undecyl ether, di-n-dodecyl, n-hexyl-n-octyl ether, n-octyl-n-decyl ether, n-decyl-n-undecyl ether, n-undecyl, n-dodecyl and n-hexyl n-undecyl ether and di-tert-butyl ether, di-iso-pentyl, 3-di-ethyldecylether, tert-butyl, n-octyl, iso-pentyl, n-octyl and 2-methyl-pentyl-n-octyl ether. The compounds 1,3-di-(2-ethylhexyl)-cyclohexane (cetiol ® S) and di-n-octyl ether (Cetiol ® OE) available as commercial products may be preferred.
- Ester oils. Ester oils are to understand the esters of C6-C30 fatty acids with C2-C30 fatty alcohols. Preferably the monoesters of fatty acids with alcohols containing 2 to 24 carbon atoms. Examples of fatty acid moieties in the esters are caproic acid, caprylic acid, 2-ethylhexanoic acid, capric acid, lauric acid, isotridecanoic, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, elaidic acid, petroselic acid, linoleic acid, linolenic acid, elaeostearic, arachidic, gadoleic, behenic acid and erucic acid and the technical mixtures thereof, for example, in the pressure hydrolysis of natural fats and oils, in the oxidation of aldehydes from Roelen oxo synthesis or the dimerization of unsaturated fatty acids occur. Examples of fatty alcohol moieties in the ester oils are isopropyl alcohol, hexanol, octanol, 2-ethylhexyl alcohol, capric alcohol, lauryl alcohol, isotridecylalcohol, myristyl alcohol, cetyl alcohol, Palmoleylalkohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, elaidyl, petroselinyl, linolyl alcohol, linolenyl, Elaeostearylalkohol, arachyl, gadoleyl, behenyl, Erucylalkohol and brassidyl and technical mixtures thereof, incurred as at the high-pressure hydrogenation of technical methyl esters based on fats and oils or aldehydes from Roelen oxo synthesis and as monomer fraction in the dimerization of unsaturated fatty alcohols. According to the invention are preferably isopropyl myristate (Rilanit ® IPM) Isononanoic acid-C16-18-alkyl esters (cetiol ® SN), 2-ethylhexyl palmitate (Cegesoft ® 24), stearic acid 2-ethylhexyl ester (cetiol ® 868), Cetyloleat, glycerol tricaprylate, Kokosfettalkoholcaprinat / caprylate (cetiol ® LC), n-butyl stearate, oleyl (cetiol ® J 600), isopropyl palmitate (IPP Rilanit ®), oleyl oleate (cetiol ®), laurate (cetiol ® A), di-n-butyl adipate (cetiol ® B ), myristyl myristate (cetiol ® MM), Cetearyl Isononanoate (cetiol ® SN), oleate (cetiol ® V).
- Dicarboxylic acid esters such as di-n-butyl adipate, di (2-ethylhexyl) adipate, di (2-ethylhexyl) sulfosuccinate and di-isotridecylacelaat and diol esters such as ethylene glycol oleate, ethylene glycol di-isotridecanoat, propylene glycol di (2 -ethylhexanoate), diisostearate propylene glycol, propylene glycol di-pelargonate, diisostearate butanediol, neopentyl glycol,
- Symmetrical, asymmetrical or cyclic esters of carbonic acid with fatty alcohols, such as described in DE-OS 197 56 454 , Glycerol or dicaprylyl (cetiol ® CC)
- Trifatty acid esters of saturated and / or unsaturated linear and / or branched fatty acids with glycerol,
- Fatty acid, which are monoglycerides, diglycerides and technical mixtures thereof. When using technical products may contain manufacturing conditions, small amounts of triglycerides.
[0056]
The amount of natural and synthetic cosmetic oil bodies present in the compositions according to the invention is usually 0.1-30 wt%, based on the total composition, preferably 0.1-20 wt -%, and in particular 0.1-15 wt -%.
[0057]
The compositions may also contain surfactants. These can be either anionic, ampholytic, zwitterionic or non-ionic surfactants and cationic surfactants.
[0058]
In a preferred embodiment of the present invention, a combination of anionic and nonionic surfactants or a combination of anionic and amphoteric surfactants is, for example, in a shampoo employed. In a hair tonic, however, the expert can also be largely or completely eliminate the use of surfactants.
[0059]
It has proved in some cases be advantageous to select the surfactants from amphoteric or nonionic surfactants.
[0060]
Suitable anionic surfactants for the present invention means all suitable for use on the human body anionic surfactants. These are characterized by a water solubilizing anionic group such as a carboxylate, sulfate, sulfonate or phosphate group and a lipophilic alkyl group having approximately 8 to 30 C-atoms. In addition, glycol or polyglycol ether groups, ester, ether, amide and hydroxyl groups may be included.
[0061]
Examples of suitable anionic surfactants are, each in the form of sodium, potassium and ammonium and mono-, di-and trialkanolammonium with 2 to 4 carbon atoms in the alkanol
- Linear and branched fatty acids containing 8 to 30 carbon atoms (soaps),
- Ether carboxylic acids of the formula RO-(CH2-CH2O) x-CH2-COOH, in which R is a linear alkyl group having 8 to 30 carbon atoms and x = 0 or 1 to 16,
- Acyl sarcosides having from 8 to 24 carbon atoms in the acyl group,
- Acyl taurides having from 8 to 24 carbon atoms in the acyl group,
- Acyl isethionates having from 8 to 24 carbon atoms in the acyl group,
- Sulfobernsteinsäuremono and dialkyl esters having 8 to 24 carbon atoms in the alkyl group and Sulfobernsteinsäuremono esters having 8 to 24 carbon atoms in the alkyl group and 1 to 6 oxyethylene groups,
- Linear alkane sulfonates having 8 to 24 C atoms,
- Linear alpha-olefin sulfonates containing 8 to 24 carbon atoms,
- Alpha-sulfofatty acid methyl esters of fatty acids having 8 to 30 C atoms,
- Alkyl sulfates and alkyl polyglycol ether sulfates of the formula RO (CH2-CH2O) x-OSO 3 H, preferably a linear alkyl group having 8 to 30 carbon atoms and wherein R x = 0 or 1 to 12,
- Mixtures of surface-active accordance hydroxysulfonates DE-A 37 25 030 ,
- Sulfated hydroxyalkyl and / or according Hydroxyalkylenpropylenglykolether DE-A 37 23 354 ,
- Sulfonates of unsaturated fatty acids having 8 to 24 carbon atoms and 1 to 6 double bonds according to DE-A 39 26 344 ,
- Represent esters of tartaric acid and citric acid with alcohols which are addition products of from about 2-15 molecules of ethylene oxide and / or propylene oxide with fatty alcohols having 8 to 22 carbon atoms, alkyl and / or alkenyl ether,
- Sulfated Fettsäurealkylenglykolester,
- Monoglyceride sulfates and monoglyceride,
- Amide ether carboxylic acids as described in the EP 0690044 are described,
- Condensation products of C8-C30 fatty alcohols with protein hydrolysates and / or amino acids and derivatives thereof which are known in the art as protein fatty acid condensates such as Lamepon ® grades Gluadin ® grades Hostapon ® KCG or Amisoft ® types.
[0062]
Preferred anionic surfactants are alkyl sulfates, alkyl polyglycol ether sulfates and ether carboxylic acids having 10 to 18 carbon atoms in the alkyl group and up to 12 glycol ether groups in the molecule, Sulfobernsteinsäuremono and dialkyl esters having 8 to 18 carbon atoms in the alkyl group and Sulfobernsteinsäuremono esters having 8 to 18 carbon atoms in the alkyl group and 1 to 6 oxyethylene groups, monoglyceride sulfates, alkyl and alkenyl ether phosphates and protein fatty acid condensates.
[0063]
Nonionic surfactants contain as hydrophilic group, eg, a polyol group, a polyalkylene glycol or a combination of polyol and polyglycol. Such compounds are for example
- Addition products of from 2 to 50 mol ethylene oxide and / or 0 to 5 mol propylene oxide onto linear fatty alcohols containing 8 to 30 carbon atoms, onto fatty acids having 8 to 30 carbon atoms and onto alkylphenols containing 8 to 15 carbon atoms in the alkyl group
- C 12-C 30 fatty acid monoesters and diesters of addition products of 1 to 30 mol ethylene oxide onto glycerol,
- C 8-C 22 alkyl mono-and oligo-glycosides and ethoxylated analogs thereof
- Addition products of from 5 to 60 mol ethylene oxide onto castor oil and hydrogenated castor oil,
- End-capped with a methyl or C2-C6 alkyl group, addition products of 2 to 50 mol ethylene oxide and / or 0 to 5 mol propylene oxide onto linear and branched fatty alcohols having 8 to 30 carbon atoms, onto fatty acids having 8 to 30 C-atoms onto alkylphenols having 8 to 15 carbon atoms in the alkyl group, such as those sold under the trade descriptions Dehydrol ® LS, LT types Dehydrol ® (Cognis),
- Polyol, such as the commercial product Hydagen ® HSP (Cognis) or Sovermol (Cognis),
- Alkoxylated triglycerides,
- Alkoxylated fatty acid alkyl esters,
- Amine oxides,
- Hydroxy mixed ethers, such as those in the DE-19738866 are described,
- Sorbitan fatty acid esters and addition products of ethylene oxide with sorbitan fatty acid esters such as the polysorbates,
- Sugar fatty acid esters and addition products of ethylene oxide with fatty acid sugar esters,
- Addition products of ethylene oxide with fatty acid and fatty amines,
- Sugar surfactants of the alkyl and alkenyl.
[0064]
Preferred nonionic surfactants are the alkylene oxide adducts have been shown to saturated linear fatty alcohols and fatty acids with 2 to 30 moles of ethylene oxide per mole of fatty alcohol or fatty acid. Preparations with excellent properties are also obtained when they present as nonionic ethoxylated fatty acid esters of glycerol.
[0065]
Particularly preferred nonionic surfactants are alkyl polyglycosides of general formula R 1 O (Z) x. These compounds are characterized by the following parameters.
[0066]
The alkyl group R 1 contains from 6 to 22 carbon atoms and may be linear or branched. Preferably, primary linear and methyl-branched in the 2-position aliphatic radicals. Such alkyl radicals are, for example, 1-octyl, 1-decyl, 1-lauryl, 1-myristyl, 1-cetyl, and 1-stearyl. Particularly preferred are 1-octyl, 1-decyl, 1-lauryl, 1-myristyl. When so-called "oxo alcohols" as starting materials, compounds with an odd number of carbon atoms in the alkyl chain.
[0067]
The invention can be used Alkylpolyglycosides example, contain only a certain alkyl radical R first Typically, these compounds are produced from natural fats and oils or mineral oils. In this case, the alkyl radicals R before the starting compounds or mixtures according to the particular working of these compounds.
[0068]
Particularly preferred are those Alkylpolyglycosides in which R 1
- Essentially of C 8 - and C 10-alkyl groups,
- Consisting essentially of C 12 - and C 14 alkyl groups,
- Consisting essentially of C 8 - to C 16-alkyl groups or
- Consisting essentially of C 12 - to C 16-alkyl groups.
[0069]
The sugar unit Z is any mono-or oligosaccharides can be used. Usually, sugars having 5 or 6 carbon atoms and the corresponding oligosaccharides are used. Sugars such as glucose, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, idose, talose and sucrose. Preferred sugar units are glucose, fructose, galactose, arabinose and sucrose, glucose being particularly preferred.
[0070]
The use in this invention Alkylpolyglycosides contain on average 1.1 to 5 sugar units. Alkylpolyglycosides with x values ​​of 1.1 to 1.6 are preferred. Very particularly preferred are alkyl glycosides in which x is 1.1 to 1.4.
[0071]
The addition to their surfactant alkyl glycosides can also be used to improve the fixation of fragrance components to the hair. The skilled person will be in the event that the duration of the hair treatment beyond desired effect of the perfume oil to the hair, preferably to fall back to this class of compounds as a further ingredient of the compositions of the invention.
[0072]
The alkoxylated homologs of the specified Alkylpolyglycosides can be used according to the invention. These homologs can average up to 10 contain ethylene oxide-propylene oxide units per alkyl glycoside and / or.
[0073]
Furthermore, in particular as co-surfactants, zwitterionic surfactants. Zwitterionic surfactants are surface-active compounds which carry at least one quaternary ammonium group and at least one-COO (-) - or-SO 3 (-) group. Particularly suitable zwitterionic surfactants are the betaines, such as N-alkyl-N, N-dimethyl ammonium glycinate, such as coconut alkyl dimethyl ammonium glycinate, N-acyl-aminopropyl-N, N-dimethyl, for example cocoacylaminopropyldimethylammonium glycinate, and 2-alkyl -3-carboxymethyl-3-hydroxyethyl imidazolines containing 8 to 18 carbon atoms in the alkyl or acyl group as well as the Kokosacylaminoethylhydroxyethylcarboxymethylglycinat. A preferred zwitterionic surfactant is known under the INCI name Cocamidopropyl Betaine fatty acid amide derivative.
[0074]
Also particularly useful as co-surfactants are ampholytic surfactants. Ampholytic surfactants are surface-active compounds which, are in addition to a C 8-C 18 alkyl or acyl group, contain at least one free amino group and at least one-COOH or-SO 3 H group in the molecule and capable of forming inner salts. Examples of suitable ampholytic surfactants are N-alkyl glycines, N-alkyl propionic acids, N-alkyl aminobutyric acids, N-Alkyliminodipropionsäuren, N-hydroxyethyl-N-alkylamido, alkyltaurines N, N-alkylsarcosines, 2-alkylamino and alkylaminoacetic with about 8 to 18 C atoms in the alkyl group. Particularly preferred surfactants are N-ampholytische cocoalkylaminopropionate, cocoacylaminoethylaminopropionate and C 12-18 acyl sarcosine.
[0075]
According to the invention are in particular those used as cationic surfactants of the quaternary ammonium compounds of the ester quat and amidoamine.
[0076]
Preferred quaternary ammonium compounds are ammonium halides, in particular chlorides and bromides, such as alkyltrimethylammonium chlorides, dialkyl dimethyl and trialkyl methyl, for example cetyltrimethylammonium chloride, stearyl trimethyl ammonium chloride, distearyldimethylammonium, lauryldimethylammonium, lauryldimethylbenzylammonium and tricetylmethylammonium chloride, and known under the INCI names Quaternium-27 and Quaternium-83 imidazolium compounds. The long alkyl chains of the abovementioned surfactants preferably have 10 to 18 carbon atoms.
[0077]
Ester quats are known substances which contain at least one ester function and at least one quaternary ammonium group as a structural element. Preferred ester quats are quaternized ester salts of fatty acids with triethanolamine, quaternized ester salts of fatty acids with diethanolalkylamines and quaternized ester salts of fatty acids with 1,2-dihydroxypropyl. Such products are marketed under the trademarks Stepantex ®, ® and Dehyquart Armocare ®. The products Armocare ® VGH-70, an N, N-bis (2-Palmitoyloxyethyl) dimethyl ammonium chloride, and Dehyquart ® F-75 and Dehyquart ® AU-35 are examples of such ester quats.
[0078]
Alkylamidoamines are usually prepared by amidation of natural or synthetic fatty acids and fatty acid fractions with dialkylaminoamines. The present invention particularly suitable compound from this group of substances under the name Tegoamid ® S 18 commercially available stearamidopropyldimethylamine dimethylamine dar.
[0079]
When used as surfactant compounds with alkyl groups may be individual substances. However, it is usually preferred to go out in the production of these substances from natural vegetable or animal raw materials so that mixtures with different alkyl chain lengths depending on the raw.
[0080]
For surfactants, the addition products of ethylene oxide and / or propylene oxide with fatty alcohols or derivatives of these addition products, both products with a "normal" homolog distribution and those can be used with a narrowed homolog distribution. Under "normal" homolog distribution are mixtures of homologs obtained as catalysts in the reaction of fatty alcohol and alkylene oxide using alkali metals, alkali metal hydroxides or alkali. Narrowed homolog distributions are obtained, if, for example, alkaline earth metal salts of ether carboxylic acids, alkaline earth metal oxides, hydroxides or alcoholates are used as catalysts. The use of products with a narrow homolog distribution may be preferred.
[0081]
Also be advantageous to use vitamins, pro-vitamins and vitamin precursors and their derivatives has been established.
[0082]
Such vitamins, pro-vitamins and vitamin precursors are preferred according to the invention, which are usually assigned to groups A, B, C, E, F, and H.
[0083]
The group of substances referred to as vitamin A retinol (vitamin A1) and 3,4-didehydroretinol include (vitamin A2). The β-carotene is the provitamin of retinol. As vitamin A components according to the invention, for example, vitamin A acid and its esters, vitamin A aldehyde and vitamin A alcohol and its esters such as palmitate and acetate. The formulations used in the invention include vitamin A component preferably used in amounts of 0.05-1 wt -%, based on the total preparation.
[0084]
The vitamin B group or the vitamin B complex include
- Vitamin B1 (thiamine)
- Vitamin B2 (riboflavin)
- Vitamin B3. Under this designation, the compounds nicotinic acid and nicotinamide (niacinamide) are frequently performed. According to the invention, the nicotinic acid, which is preferably in accordance with the invention the agents used in amounts of 0.05 to 1 wt -% is contained, based on the total composition.
- Vitamin B5 (pantothenic acid, panthenol and Pantolacton). Within this group, panthenol and / or Pantolacton is preferably used. Used according to the invention are derivatives of panthenol in particular the esters and ethers of panthenol and cationically derivatized panthenols. Individual representatives are, for example, panthenol, panthenol and its monoacetate, and in the WO 92/13829 disclosed cationic panthenol. The compounds of the vitamin B5 type mentioned are preferred in the compositions according to the invention in amounts of 0.05-10 wt -%, based on the total composition. Amounts of 0.1-5 wt -% are particularly preferred.
- Vitamin B6 (pyridoxine and pyridoxamine and pyridoxal).
[0085]
Vitamin C (ascorbic acid). Vitamin C is present in the compositions according to the invention preferably in amounts of 0.1 to 3 wt -%, based on the total composition. Use in the form of palmitic acid ester, the glucosides or phosphates may be preferred. The use in combination with tocopherols may also be preferred.
[0086]
Vitamin E (tocopherols, in particular α-tocopherol). Tocopherol and its derivatives, including in particular the esters such as the acetate, nicotinate, succinate, and phosphate are present in the compositions according to the invention preferably in amounts of 0.05-1 wt -%, based on the total composition .
[0087]
Vitamin F. The term "vitamin F" usually are essential fatty acids, especially linoleic acid, linolenic acid and arachidonic acid, understood.
[0088]
Vitamin H. The compound (3aS, 4S, 6aR)-2-oxohexahydrothienol [3,4-d] imidazole-4-valeric acid is referred to as vitamin H, but for which the trivial name has prevailed biotin. Biotin is used in the compositions according to the invention preferably in amounts of from 0.0001 to 1.0 wt -% of -%, in particular in amounts of from 0.001 to 0.01 wt.
[0089]
Preferably, the preparations according to the invention contain vitamins, pro-vitamins and vitamin precursors from the groups A, B, E and H. Of course, several vitamins and vitamin precursors may be present simultaneously.
[0090]
Panthenol, Pantolacton, pyridoxine and its derivatives and nicotinamide and biotin are particularly preferred.
[0091]
The amount of vitamins and vitamin precursors in the compositions according to the invention is usually 0.0001-10% by weight based on the total composition, preferably from 0.0001-5 wt -%, and particularly from 0.0001 to 3 wt -% .
[0092]
Finally, other plant extracts can be used in the inventive compositions.
[0093]
These extracts are prepared by extraction of the whole plant. But it may also be preferable in some cases to prepare the extracts exclusively from flowers and / or leaves of the plant.
[0094]
With regard to the plant extracts used in the present invention is made in particular to the extracts, in the on page 44 of the 3rd Edition of the Guide to the cosmetic ingredient declaration, issued by the Industrial Association of Personal Care and Detergent Association (WBB), Frankfurt, starting table are listed.
[0095]
According to the invention, the extracts from green tea, oak bark, stinging nettle, hamamelis, hops, henna, chamomile, burdock root, horsetail, hawthorn, linden blossom, almond, aloe vera, pine needle, horse chestnut, sandalwood, juniper, coconut, mango, apricot, lemon , wheat, kiwi, melon, orange, grapefruit, sage, rosemary, birch, mallow, lady's smock, wild thyme, yarrow, thyme, lemon balm, restharrow, coltsfoot, marshmallow, meristem, ginseng and ginger root.
[0096]
In this case, one or more of these plants extracts used in products containing active substances which are obtainable from plants of the genus Harpagophytum be used.
[0097]
The plant extracts according to the invention can be used either in pure form or in dilute form. If they are used in a diluted form, they usually contain about 2-80 wt -% of active substance and the extractant or extractant mixture used in their production as a solvent.
[0098]
With regard to other optional components and the amounts used explicitly to the relevant known in the art manuals, eg Kh Schrader, Fundamentals and Formulations of Cosmetics, 2nd Edition, Huthig Buch Verlag, Heidelberg, 1989, referred to.
[0099]
Accordingly, an object of the present invention is the use of an agent comprising active ingredients, which are obtainable from plants of the genus Harpagophytum, the agent may contain additional ingredients selected from the group consisting of protein hydrolysates, film-forming substances other hair-growth stimulating agents, nonionic surfactants, anioische surfactants, zwitterionic surfactants, ampholytic surfactants, nonionic polymers, thickeners, perfume oils, dyes, light stabilizers, antioxidants, anti-dandruff agents, propellants, reducing agents.
[0100]
The proportion of the active ingredients from Harpagophytumpflanzen is preferably 0.001 to 10 wt -% of the total composition.
[0101]
In particular, an object of the present invention is a hair treatment composition comprising active ingredients, which are obtainable from plants of the genus Harpagophytum. A treatment composition can be a shampoo, hair rinses, hair gel, hair lotion, hair treatment, hair cream, hair lotion, hair spray or a Haartrinktur.
[0102]
Another object of the present invention is the use, in particular the cosmetic use of vitalising hair, reactivation of the hair root, stimulation of energy metabolism in hair follicles, activation of hair follicles, promoting or enhancing hair growth, hair thickening, hair loss treatment and to influence (especially excitation ) of keratin, or for conditioning hair.
[0103]
Very particular preference is given to the use of an agent comprising active ingredients, which are obtainable from plants of the genus Harpagophytum for the treatment of hair. Very particular preference is the use of a composition containing active ingredients that are available to reactivate from plants of the genus Harpagophytum to stimulate hair growth and the hair root, especially in places where the hair growth is set up and running.
[0104]
The reactivation and stimulate the hair root causes according to the invention in particular through the repression of certain genes haarwuchsinhibierenden in the dermal papilla. Therefore, a further preferred embodiment of the present invention, the use of compositions comprising active ingredients, which are obtainable from plants of the genus Harpagophytum for reactivation of the hair root and hair by the suppression and / or reducing haarwuchsinhibierenden genes in the dermal papilla.
[0105]
A further object of the present invention is a method, in particular a cosmetic method for revitalizing hair, reactivation of the hair root, hair thickening stimulating keratin synthesis, stimulation of energy metabolism in the hair follicle, activation of hair follicles, promoting or enhancing the growth of hair or for hair conditioning, characterized in that applying a composition comprising active ingredients, obtainable from plants of the genus Harpagophytum, to the hair or to the scalp.
[0106]
Por malagueñocalvo  -  Cinturón Naranja  - 214Mensajes
#443164
hilo interesante que he visto en hairlosstalk

Melatonina - disponible en todas las farmacias. Micromolar o mayores concentraciones de melatonina redujo significativamente la conversión de [3H] ácido araquidónico a prostaglandina (PG) F2 y el tromboxano (Tx) B2, y inhibieron ligeramente la conversión de PGE2 y PGD2.
http://www.ncbi.nlm.nih.gov/pubmed/1795220
Además, la melatonina contrarresta el efecto inhibidor de PGE2 en la producción de IL-2 en linfocitos humanos a través de su receptor de membrana MT1.
http://www.ncbi.nlm.nih.gov/pubmed/12594180
Esto es bastante decepcionante, especialmente como la melatonina se ha demostrado hacer crecer el cabello de los hombres en un estudio especializado.

El resveratrol reduce potencialmente la producción de prostaglandina E2 y la formación de radicales libres en microglia rata primaria lipopolisacáridos activado.
http://www.jneuroinflammation.com/content/4/1/25
Muy lamentable. El resveratrol es que se puede obtener en forma de extracto puro en línea y en algunas tiendas especializadas.

La quercetina suprime la expresión de la ciclooxigenasa-2 y la angiogénesis a través de la inactivación de la señalización de P300. Se suprimió significativamente la COX-2 mRNA y expresión de proteínas y la producción de PGE2, así como la COX-2 activación del promotor en células de cáncer de mama. La quercetina también inhibió significativamente la angiogénesis mediada por COX-2 en células endoteliales humanas de una manera dependiente de la dosis.
http://www.plosone.org/article/info%...l.pone.0022934
Muy decepcionante. La quercetina es que se puede obtener en algunas farmacias y como un extracto puro en línea.

La curcumina - inhibición de la supervivencia celular y la inducción de apoptosis por cúrcuma en líneas celulares de adenocarcinoma colorrectal se asocia con la inhibición de la síntesis de PGE2 y baja regulación de la COX-2.
http://www.ncbi.nlm.nih.gov/pubmed/16737669
Muy decepcionante. La curcumina disponible como suplemento dieatary, posiblemente también en grandes cantidades en alguna parte.

El ácido ascórbico (vitamina C) dosis-dependiente inhibe la interleucina-1 beta (IL-1 beta) mediada por la síntesis de PGE2 en la línea celular neuronal humano. Además, dosis-dependentlyproduced una reducción significativa en la producción mediada por IL-1beta de 8-iso-prostaglandina F2 alfa (PGF2a), un indicador fiable de la formación de radicales libres, lo que sugiere que los efectos del ácido ascórbico sobre mediada por COX-2 biosíntesis de PGE2 puede ser el resultado del mantenimiento del estado redox neuronal ya que se conoce la actividad de COX ser mejorada por el estrés oxidativo.
http://arxiv.org/abs/0708.0548
Esto puede no ser tan malo como parece como la síntesis de PGE2 en este caso particular fue mediada por IL1b y posiblemente por los radicales libres. Todavía es una pequeña advertencia y un resto para mí estudiar este antioxidante en particular un poco más. Esto debido a que pocos otros estudios confirmaron que el ácido L-ascórbico 2-fosfato o ácido L-ascórbico tópico deben apoyar directamente el crecimiento del cabello:
http://www.ncbi.nlm.nih.gov/pubmed/20701628
http://www.jdsjournal.com/article/S0...1471-5945/4/13
Veredicto - en espera. Lo estoy usando tópicamente con MSM, lo sabré en 5 meses. Disponible y demasiado caro como un suplemento en las farmacias, pero también muy barato en grandes cantidades como un aditivo alimentario.

La vitamina E (tocoferol, tocotrienol) - suplementación con vitamina E succinato resultó en una disminución significativa en los niveles de PGD2, mientras que los niveles PGF2alfa se redujo significativamente. Células BL6-F10 suplementado con 7 y 10 microg / ml de vitamina E succinato mostraron un marcado incremento en los niveles de PGE2 con un aumento significativo que ocurre en 10 microg / ml. Niveles de PGI2 siguieron una tendencia similar a la PGE2 con un aumento significativo que ocurre en 10 microg / ml.
http://www.ncbi.nlm.nih.gov/pubmed/9223656
Veredicto - cauto optimismo. No hay resultados reales relacionados con la pérdida de cabello situación / crecimiento aquí. Disponible como suplemento.

La vitamina D (calcitriol) - inhibición de COX-2 y estimular la expresión 15-PGDH, calcitriol disminuyó los niveles de prostaglandinas biológicamente activos en células de cáncer de próstata, reduciendo así la estimulación del crecimiento por las prostaglandinas. Calcitriol también inhibe la expresión de la PG receptores EP2 y FP.
http://www.researchgate.net/profile/...14f5d7f9000000
http://jn.nutrition.org/content/137/1/205S.full
http://www.ncbi.nlm.nih.gov/pubmed/16886660
La vitamina D disponibles en todas partes. Y lo más posiblemente bastante inútil para hairgrowth.

El té verde también es culpable, asociada con una reducción en los niveles de la ciclooxigenasa (COX) -2, la prostaglandina receptores (PG) E2 y PGE2 (EP2 y EP4). La ingestión de té verde disminuye rápidamente los niveles de prostaglandina E2 en la mucosa rectal en seres humanos.
http://www.ncbi.nlm.nih.gov/pubmed/10744131
http://www.plosone.org/article/info%...l.pone.0025224


Así que ¿qué hay de eso, ¿eh?

Yo creo que no todo está perdido para estos compuestos. Si lo que desea es dejar que la caída del cabello / vertimiento, que probablemente podría utilizar algún tipo de combinación de un AINE y algún suplemento de lo anterior (ácido ascórbico especial actualidad debe complementar AINEs sistémicos muy bien, tal vez junto con calcitriol tópica y la melatonina). Los resultados que obtendrá de la disminución de la COX-es podría ser visible en su caída del cabello / derramando en cuestión de días, si no horas.

El crecimiento del cabello es otro capítulo. Algunos de estos compuestos son francamente inadecuado para cualquier situación crecimiento del cabello. Creo que hay que buscar en otra parte [del crecimiento del pelo].


Cita Iniciado por espectador Ver Mensaje
que debería estar bloqueando PGD2 también bloquean PGE2.
Esto también se observó en el original Garza et al, papel (prostaglandina D2 inhibe el crecimiento del cabello y es elevada en el cuero cabelludo calvo de los hombres con alopecia androgenética.) Para la aspirina.:

"Nuestros resultados sugieren que en el ratón y la piel humana, un equilibrio entre PGE2 y PGD2 controla el crecimiento del cabello. Este modelo predice entonces que los esfuerzos para revertir la alopecia deben centrarse de forma óptima tanto en la mejora de PGE2 y la inhibición de la señalización PGD2. Este modelo explica también por qué los agentes tales como la aspirina, que inhiben la síntesis de prostaglandinas enzimas aguas arriba (PTGS1 y PTGS2), tiene efectos mínimos sobre el crecimiento del cabello debido probablemente igual de disminución de la producción de PGE2 y PGD2 ".



sip. Es ahora un hecho conocido por AINE como la aspirina. Esta discusión es sobre los antioxidantes y suplementos dietéticos sin embargo.



¿Cuál es la cura? Curar a qué? Yo no escribo sobre cualquier cura .. Simplemente escribí acerca de los suplementos que en combinación con AINEs puede detener la caída del cabello (no necesariamente crecer el pelo). Usted teóricamente no tendría ningún problema PGD2 pero vía de señalización Wnt todavía estarían fuera, los andrógenos podrían todavía estar presente y por lo tanto, probablemente no se le impida toda pérdida de cabello.

Esto es exactamente por qué nadie tiene tanto los resultados utilizando los antioxidantes o antiinflamatorios no esteroideos. Incluso si apaga COX1 y COX2, todavía hay mucho queda por reconstruir en el gran rompecabezas de la AGA.

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Navegación Rápida Nueva Investigación, Estudios y Tecnologías Top
Por slovak  -  Cinturón Naranja  - 467Mensajes
#443322
malagueñocalvo escribió:hilo interesante que he visto en hairlosstalk

Melatonina - disponible en todas las farmacias. Micromolar o mayores concentraciones de melatonina redujo significativamente la conversión de [3H] ácido araquidónico a prostaglandina (PG) F2 y el tromboxano (Tx) B2, y inhibieron ligeramente la conversión de PGE2 y PGD2.
http://www.ncbi.nlm.nih.gov/pubmed/1795220
Además, la melatonina contrarresta el efecto inhibidor de PGE2 en la producción de IL-2 en linfocitos humanos a través de su receptor de membrana MT1.
http://www.ncbi.nlm.nih.gov/pubmed/12594180
Esto es bastante decepcionante, especialmente como la melatonina se ha demostrado hacer crecer el cabello de los hombres en un estudio especializado.
sobre contrarrestar el efecto inhibidor sobre la producción de Il2 y no se qué historias:

De verdad tiene tanta trascendencia como para calificarlo de decepcionante?? lo pregunto por desconocimiento total

¿es una manera de contradecir los supuestos beneficios de la melatonina tópica ( creo que se desconoce la causa de su efecto en los estudios que lo avalan) o que perjudica por otra vía??

Joder, es que me jode ahora que estoy con el cosmético Lambdapil y me viene de fábula para la Ds. Luego si suena la flauta con la fase anagena o crecimiento de nuevo cabello, pues de puta madre. pero no le pido mucho más mientras todo el tinglado tan enrevesado de las Postag no haga estragos en mi ciclo capilar
Por malagueñocalvo  -  Cinturón Naranja  - 214Mensajes
#444654
He estado leyendo un post sobre el saba gel y en el se habla de la utilización del aceite de emú combinado con retin A como sustituto del mismo, debido a los posibles efectos secundarios de la betametasona

Quizás una fórmula con aceite de emú más retin A y vitamina E, sería una fórmula más que interesante

Lo que no tengo muy claro es como ponerlas en una base, supongo que el alcohol no, porque no pueden disolverse, sería ponerlas en otro aceite vehiculizante y a su vez sería algo pegajoso no?

los que utilizais el aceite de emú como lo hacéis?

Se le puede echar agua destilada para que no quede tan denso?

Gracias.

Si me entero de algo os aviso.
Por Atento  -  Cinturón Rojo  - 1300Mensajes
#530859
Este hilo es de lo mejor que vi hasta ahora. Que habrá pasado con esos foreros como este:
AliceCooper escribió:el té de rooibos parece ser un antihistamínico suave, venden bolsitas para infusiones en el Mercadona...

y un antiinflamatorio, como el té verde y libre de cafeína:

http://www.ncbi.nlm.nih.gov/pubmed/19419525
http://te.innatia.com/c-te-rooibos-prop ... oibos.html

Ese té parece de lo mejor que puede haber, además de todo eso sería alergénico, antiinflamatorio, bueno para el stress, el hígado groaso y fijar el zinc!

En todo este tiempo surgieron otros inhibidores que los que aquí se detallan?
Por Atento  -  Cinturón Rojo  - 1300Mensajes
#530899
disintegrants for example potato starch, or acceptable wetting agents such as sodium lauryl sulphate.